Physical Models of Collective Cell Migration
نویسندگان
چکیده
منابع مشابه
Physical forces during collective cell migration
Fundamental biological processes including morphogenesis, tissue repair and tumour metastasis require collective cell motions1–3, and to drive these motions cells exert traction forces on their surroundings4. Current understanding emphasizes that these traction forces arise mainly in ‘leader cells’ at the front edge of the advancing cell sheet5–9. Our data are contrary to that assumption and sh...
متن کاملPhysical models of collective cell motility: from cell to tissue.
In this article, we review physics-based models of collective cell motility. We discuss a range of techniques at different scales, ranging from models that represent cells as simple self-propelled particles to phase field models that can represent a cell's shape and dynamics in great detail. We also extensively review the ways in which cells within a tissue choose their direction, the statistic...
متن کاملCollective guidance of collective cell migration.
Some cells migrate and find their way as solitary entities. However, during development of multicellular animals and possibly during tumor dissemination, cells often move as groups, associated tightly or loosely. Recent advances in live imaging have aided examination of such 'multicellular cell biology'. Here, I propose a model for how a group of cells can process and react to guidance informat...
متن کاملEquation-Based Models of Wound Healing and Collective Cell Migration
Wound healing is a physiological process of repair of a tissue that has been structurally damaged. The most common wounds disrupt one of the epithelial tissues that protect the internal and external surfaces of the body and act as barriers against invasion by microorganisms. Such tissues include skin, corneal tissue, and the epithelial lining of the digestive tract (including the mouth and esop...
متن کاملCollective cell migration in development
During embryonic development, tissues undergo major rearrangements that lead to germ layer positioning, patterning, and organ morphogenesis. Often these morphogenetic movements are accomplished by the coordinated and cooperative migration of the constituent cells, referred to as collective cell migration. The molecular and biomechanical mechanisms underlying collective migration of developing t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Annual Review of Condensed Matter Physics
سال: 2020
ISSN: 1947-5454,1947-5462
DOI: 10.1146/annurev-conmatphys-031218-013516